GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs6951245 | 1 | rs80031817 | chr7:1096793 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs7714584 | 1 | rs80075680 | chr5:150223737 | LOC134466 | chr5:150310000-150326146:- | 0.44 | 5.43 | 1.01E-7 | Crohn's disease |
| BLCA | cis | rs6951245 | 1 | rs80094748 | chr7:1103958 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.37 | 1.62E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs8010715 | 1 | rs8010715 | chr14:24609147 | FAM158A | chr14:24608175-24610797:- | -0.42 | -8.03 | 1.2E-14 | IgG glycosylation |
| BLCA | cis | rs2143950 | 1 | rs8013540 | chr14:35513760 | PPP2R3C | chr14:35554679-35591679:- | 0.25 | 3.86 | 0.000131 | Atopic dermatitis |
| BLCA | cis | rs2985684 | 1 | rs8014170 | chr14:50071694 | RPL36AL | chr14:50085407-50087349:- | 0.26 | 4.65 | 4.66E-6 | Carotid intima media thickness |
| BLCA | cis | rs17108533 | 1 | rs8015636 | chr14:71226559 | MAP3K9 | chr14:71194856-71275888:- | 0.42 | 4.43 | 1.25E-5 | Response to antipsychotic treatment in schizophrenia (reasoning) |
| BLCA | cis | rs8018967 | 1 | rs8018967 | chr14:73976934 | HEATR4 | chr14:73945193-74025651:- | -0.23 | -4.03 | 6.77E-5 | Blood metabolite ratios |
| BLCA | cis | rs80285556 | 1 | rs80202648 | chr19:50494386 | SIGLEC16 | chr19:50472912-50479075:+ | 0.59 | 5.59 | 4.42E-8 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| BLCA | cis | rs6951245 | 1 | rs80212261 | chr7:1114012 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.43 | 1.26E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs11622475 | 1 | rs8021692 | chr14:104428576 | TDRD9 | chr14:104394817-104519002:+ | 0.31 | 4.7 | 3.57E-6 | Bipolar disorder |
| BLCA | cis | rs80285556 | 1 | rs80285556 | chr19:50540170 | SIGLEC16 | chr19:50472912-50479075:+ | 0.48 | 4.68 | 4.04E-6 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| BLCA | cis | rs2120019 | 1 | rs8033837 | chr15:75353975 | SCAMP5 | chr15:75287901-75313836:+ | 0.29 | 4.83 | 1.97E-6 | Blood trace element (Zn levels) |
| BLCA | cis | rs78153629 | 1 | rs8033938 | chr15:40703114 | C15orf23 | chr15:40674922-40686488:+ | 0.35 | 5.94 | 6.5E-9 | Heschl's gyrus morphology |
| BLCA | cis | rs9788721 | 1 | rs8034191 | chr15:78806023 | CHRNA5 | chr15:78857906-78886458:+ | -0.26 | -4.12 | 4.73E-5 | Post bronchodilator FEV1;Emphysema imaging phenotypes;Local histogram emphysema pattern;Emphysema distribution in smoking;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |